Programmed death 1, ligand 1 and 2 correlated genes and their association with mutation, immune infiltration and clinical outcomes of hepatocellular carcinoma

Figure 2 Co-mutation plot of highly frequent mutations in liver cancer. Mutational frequencies are given in a bar plot beside the co-mutation plot. Overall mutation load as the total number of mutations in each patient is presented in the top barplot. Programmed death 1/programmed death ligand 1/programmed death ligand 2 expression is illustrated in a heatmap in the panel below. Clinical data including age, stage, and recurrence event are shown in the top panel. TP53: Tumor suppressor protein p53; CTNNB1: Catenin beta 1; TTN: TITIN; CACNA1E: Calcium voltage-gated channel subunit alpha1 E; RYR: Ryanodine receptor; PD-1: Programmed death 1; PD-L1: Programmed death ligand 1; PD-L2: Programmed death ligand 2.