Decreased expression of the long non-coding RNA HOXD-AS2 promotes gastric cancer progression by targeting HOXD8 and activating PI3K/Akt signaling pathway

Figure 5 HOXD8 is downregulated in human gastric cancer tissues and positively correlated with HOXD-AS2 expression. A: CirclncRNAnet database analysis results show that HOXD-AS2 is positively correlated with HOXD8 (r = 0.785, P < 0.05); B: Bivariate correlation analysis of the relationship between HOXD-AS2 and HOXD8 expression levels, and the resulting Spearman correlation coefficient was calculated as 0.9157 with P < 0.0001 (n = 79); C and D: The relative mRNA expression level of HOXD8 was decreased in human gastric cancer (GC) tissues (P = 0.048); E and F: The relative protein expression levels of HOXD8 were decreased in human GC cells (P < 0.001); G and H: The relative protein expression level of HOXD8 was decreased in human GC tissues (P < 0.001). The results are shown as the mean ± SD. ^aP < 0.05, ^eP < 0.001. GC: Gastric cancer; ANTs: Adjacent non-cancerous tissues.