Diagnostic value of serum human epididymis protein 4 in esophageal squamous cell carcinoma

Table 4 Summary of sensitivity and specificity of each biomarker in combination with each other

Variable combination	AUC	Standard error	Asymptotic significance	Asymptotic 95%CI
HE4 + CEA	0.828	0.034	0.000	0.761-0.895
HE4 + AFP	0.819	0.036	0.000	0.748-0.890
HE4 + CA19-9	0.837	0.034	0.000	0.770-0.904
CEA + AFP	0.775	0.041	0.000	0.696-0.855
CEA + CA19-9	0.790	0.039	0.000	0.713-0.867
AFP + CA19-9	0.717	0.045	0.000	0.635-0.805

AUC: Area under the curve; HE4: Human epididymis protein 4; CEA: Carcinoma embryonic antigen; AFP: Alpha fetal protein; CA19-9: Carbohydrate antigen 19-9.