Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

Table 5 Univariate and multivariate analyses of overall survival of 65 gastric cancer patients in younger group (age < 45 yr)

Characteristic	Univariate	Analysis	Multivariate	Analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex (Male/Female)		0.555
Hospitalization (≥ 18/< 18 mo)	2.698 (1.153-6.312)	0.022		0.072
T stage (3 + 4/1 + 2)	60.674 (2.194-1677.654)	0.015
N stage (1-3/0)	8.062 (2.361-27.534)	0.01
M stage (1/0)	6.437 (2.599-15.946)	< 0.001
TNM (III-IV/I-II)	10.933 (3.217-37.162)	< 0.001	9.253 (2.644-32.377)	< 0.001
Location (Cardia/non-cardia)	3.684 (1.344-10.092)	0.011		0.301
Tumor size (≥ 4/< 4 cm)	4.293 (1.599-11.527)	0.004		0.271
Histological type (Diffuse/Intestinal)		0.161
Neural invasion (Y/N)		0.63
Vessel invasion (Y/N)	4.518 (1.988-10.266)	< 0.001	2.898 (1.249-6.723)	0.013
Esophageal invasion (Y/N)		0.31
NLR (≥ 2.6/< 2.6)	2.878 (1.257-6.588)	0.012		0.445
Anemia (Y/N)		0.094
PLR (≥ 133/<133)	3.083 (1.148-8.276)	0.025		0.958
Low albumin (Y/N)		0.295
Low prealbumin (Y/N)		0.051
PNI (< 47/≥ 47)	2.760 (1.178-6.466)	0.019		0.244

TNM: Tumor–node–metastasis; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet lymphocyte ratio; PNI: Prognostic nutritional index.