Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

Table 3 Univariate and multivariate analyses of overall survival of 716 gastric cancer patients in younger group (age < 70 yr)

Characteristic	Univariate	Analysis	Multivariate	Analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex (Male/Female)	0.983 (0.765-1.263)	0.893
Hospitalization (≥ 18/< 18 mo)	2.439 (1.909-3.115)	< 0.001	1.801 (1.394-2.327)	< 0.001
T stage (3 + 4/1 + 2)	9.948 (6.242-15.855)	< 0.001
N stage (1-3/0)	6.841 (4.797-9.756)	< 0.001
M stage (1/0)	5.799 (4.278-7.860)	< 0.001
TNM (III-IV/I-II)	7.791 (5.586-10.867)	< 0.001	5.418 (3.731-7.869)	< 0.001
Location (Cardia/non-cardia)	1.567 (1.190-2.064)	< 0.001	1.042 (0.753-1.441)	0.804
Tumor size (≥ 4/< 4 cm)	2.962 (2.267-3.871)	< 0.001	1.123 (0.831-1.517)	0.452
Histological type (Diffuse/Intestinal)	1.661 (1.311-2.105)	< 0.001	1.249 (0.973-1.604)	0.081
Neural invasion (Y/N)	2.024 (1.573-2.604)	< 0.001	0.987 (0.758-1.286)	0.925
Vessel invasion (Y/N)	2.865 (2.260-3.632)	< 0.001	1.501 (1.163-1.936)	0.002
Esophageal invasion(Y/N)	2.197 (1.566-3.082)	< 0.001	1.214 (0.814-1.810)	0.341
NLR (≥ 2.6/< 2.6)	1.602 (1.267-2.024)	< 0.001	1.151 (0.881-1.505)	0.303
Anemia (Y/N)	1.282 (1.004-1.637)	0.046	0.746 (0.559-0.995)	0.046
PLR (≥ 133/< 133)	1.540 (1.217-1.948)	< 0.001	1.102 (0.835-1.453)	0.493
Low albumin (Y/N)	1.585 (1.117-2.249)	0.010	0.781 (0.515-1.183)	0.243
Low prealbumin (Y/N)	2.149 (1.688-2.735)	< 0.001	1.637 (1.254-2.138)	< 0.001
PNI (< 47/≥ 47)	1.839 (1.444-2.343)	< 0.001	1.226 (0.896-1.679)	0.203

TNM: Tumor–node–metastasis; NLR: Neutrophil-lymphocyte ratio; PLR: Platelet lymphocyte ratio; PNI: Prognostic nutritional index.