Comparison of prognostic factors in different age groups and prognostic significance of neutrophil-lymphocyte ratio in patients with gastric cancer

Table 1 General characteristics and overall survival among 1038 gastric cancer patients

Characteristic	Patients n (%)	Overall survival months (95%CI)	P value
Sex			0.864
Male	728 (70.2%)	59.6 (56.9-62.2)
Female	309 (29.8%)	59.7 (55.7-63.8)
Age (yr)			< 0.001
< 70	716 (69%)	64.7 (62.2-67.3)
≥ 70	321 (31%)	48.1 (44.1-52.2)
Hospitalization (d)			< 0.001
< 18	494 (47.6%)	68.7 (65.7-71.6)
≥ 18	543 (52.4%)	51.5 (48.4-54.6)
TNM stage			< 0.001
I	251 (24.2%)	87.1 (84.9-89.2)
II	197 (19.0%)	75.5 (71.4-79.5)
III	509 (49.1%)	46.2 (43.1-49.2)
IV	80 (7.7%)	19.1 (14.5-23.8)
Tumor size (cm)			< 0.001
< 4	405 (39.1%)	75.2 (72.3-78.1)
≥ 4	632 (60.9%)	49.7 (46.8-52.6)
Lymph node metastasis (N)			< 0.001
0	393 (37.9%)	80.6 (78.1-83.2)
1-3	644 (62.1%)	46.8 (44.0-49.6)
Distant metastasis (M)			< 0.001
0	957 (92.3%)	62.9 (60.7-65.2)
1	80 (7.7%)	19.1 (14.5-23.8)
Tumor location			< 0.001
Cardia	200 (19.3%)	50.9 (45.9-56.0)
Non-cardia	837 (80.7%)	61.7 (59.2-64.1)
Hematological type			< 0.001
Intestinal type	555 (53.5%)	64.5 (61.6-67.4)
Diffuse type	482 (46.5%)	53.9 (50.6-57.2)
Depth of invasion			< 0.001
1-2	313 (30.2%)	84.4 (82.0-86.8)
3-4	724 (69.8%)	48.9 (46.3-51.6)
Neural invasion			< 0.001
No	822 (74.3%)	63.1 (60.7-65.6)
Yes	215 (25.7%)	45.9 (41.1-50.7)
Vessel invasion			< 0.001
No	771 (74.3%)	65.7 (63.2-68.1)
Yes	266 (25.7%)	42.0 (37.7-46.3)
Esophageal invasion			< 0.001
No	949 (91.5%)	61.6 (59.3-63.9)
Yes	88 (8.5%)	38.7 (31.5-45.8)
NLR			< 0.001
< 2.6	634 (61.1%)	64.5 (61.8-67.3)
≥ 2.6	382 (38.9%)	51.8 (48.2-55.5)
HB (g/L)			< 0.001
< 120	407 (39.2%)	53.2 (49.6-56.8)
≥ 120	630 (60.8%)	63.8 (61.1-66.6)
PLR			< 0.001
< 133	486 (46.9%)	64.9 (61.8-68.0)
≥ 133	551 (53.1%)	54.9 (51.8-58.0)
Albumin			< 0.001
< 35	165 (15.9%)	46.4 (40.8-52.0)
≥ 35	872 (84.1%)	62.1 (59.8-64.5)
Pre-albumin			< 0.001
< 212	354 (34.1%)	45.7 (41.8-49.5)
≥ 212	683 (65.9%)	66.9 (64.3-69.4)
PNI			< 0.001
< 47	387 (37.3%)	48.3 (44.7-52.0)
≥ 47	65 (62.7%)	66.4 (63.7-69.0)

TNM: Tumor–node–metastasis; NLR: Neutrophil-lymphocyte ratio; HB: Hemoglobin; PLR: Platelet lymphocyte ratio; PNI: Prognostic nutritional index.