Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China

Table 2 Clinicopathological characteristics of gastric cancer patients at different time periods, n (%)

	2000-2004 (n = 647)	2005-2009 (n = 1452)	2010-2014 (n = 2645)	2000-2014 (n = 4744)	P value
Gender					0.321
Male	462 (71.4)	1079 (74.3)	1961 (74.1)	3502 (73.8)
Female	185 (28.6)	373 (25.7)	684 (25.9)	1242 (26.2)
Age (yr)					0.000
≤ 45	110 (17)	177 (12.2)	286 (10.8)	573 (12.1)
45-65	362 (56)	822 (56.6)	1695 (64.1)	2879 (60.7)
> 65	175 (27)	453 (31.2)	664 (25.1)	1292 (27.2)
Tumor location					0.017
Upper third	74 (11.4)	158 (10.9)	336 (12.7)	568 (12)
Middle third	89 (13.8)	237 (16.3)	343 (13)	669 (14.1)
Lower third	373 (57.7)	836 (57.6)	1586 (60)	2795 (58.9)
Whole stomach	115 (17.8)	221 (15.2)	380 (14.3)	712 (15)
Tumor size (mm)					0.000
< 50	192 (29.7)	593 (40.8)	1105 (41.8)	1890 (39.8)
≥ 50	455 (70.3)	859 (59.2)	1540 (58.2)	2854 (60.2)
Histologic type					0.000
Well/moderately differentiated	184 (28.4)	492 (33.9)	1101 (41.6)	1777 (37.5)
Lowly/undifferentiated	463 (71.6)	960 (66.1)	1544 (58.4)	2967 (62.5)
T stage					0.000
T1	25 (3.9)	121 (8.3)	380 (14.4)	526 (11.1)
T2	112 (17.3)	197 (13.6)	258 (9.8)	567 (12)
T3	110 (17)	155 (10.7)	820 (31)	1085 (22.9)
T4	400 (61.8)	979 (67.4)	1187 (44.9)	2566 (54.1)
N stage					0.000
N0	226 (34.9)	493 (34)	999 (37.8)	1717 (36.2)
N1	195 (30.1)	285 (19.6)	407 (15.4)	888 (18.7)
N2	126 (19.5)	217 (14.9)	422 (16)	765 (16.1)
N3	100 (15.5)	457 (31.5)	817 (30.9)	1374 (29)
M stage					0.000
M0	572 (88.4)	1352 (93.1)	2484 (93.9)	4408 (92.9)
M1	75 (11.6)	100 (6.9)	161 (6.1)	336 (7.1)
TNM stage					0.000
I	65 (10)	184 (12.7)	468 (17.7)	717 (15.1)
II	167 (25.8)	360 (24.8)	587 (22.2)	1114 (23.5)
III	340 (52.6)	808 (55.6)	1429 (54)	2577 (54.3)
IV	75 (11.6)	100 (6.9)	161 (6.1)	336 (7.1)

TNM: Tumor-node-metastasis.