Abnormal CD44 activation of hepatocytes with nonalcoholic fatty accumulation in rat hepatocarcinogenesis

Figure 1 Rat livers with lipid accumulation and circulating lipid levels. A: The livers of control rats with normal diet; B: The livers of the rats with high fat diet; C: The livers of the rats with high fat plus 2-fluorenylacetamide (2-FAA) diet at the early stage; D: The livers of the rats with high fat plus 2-FAA diet at the middle early stage; and E: The livers of the rats with high fat plus 2-FAA diet at the last stage; A1: Normal controls; B1-E1: The sections of the corresponding to above livers were stained with the Oil red O assay, and over lipid accumulation in rat hepatocytes; F: The integral optic density values represented hepatic lipid levels of the corresponding to above livers; G: The alterations of serum total cholesterol level; and H: The alterations of serum triglycerides level. Original magnification of liver sections (× 400) from Figure 1A1 to Figure 1E1. ^aP < 0.05 vs control group. IOD: Integral optic density; Tch: Total cholesterol; TG: Triglycerides.