Retrospective evaluation of lymphatic and blood vessel invasion and Borrmann types in advanced proximal gastric cancer

Table 2 Univariate and multivariate analysis of prognostic factors in 440 patients with advanced proximal gastric cancer after curative resection

	Univariate analysis		Multivariate analysis
	Hazard ratio (95%CI)	P value	Hazard ratio (95%CI)	P value
Age (yr)
> 60 vs ≤ 60	1.295 (1.031-1.628)	0.026	1.206 (0.928-1.567)	0.161
Tumor size (cm)
> 5 vs ≤ 5	2.118 (1.648-2.722)	0.000	1.246 (0.922-1.684)	0.153
Adjacent organs invaded1
With vs Without	1.630 (1.264-2.102)	0.000	1.436 (1.074-1.919)	0.015
Histologic differentiation
Poor vs well	1.370 (1.088-1.725)	0.007	1.278 (0.980-1.666)	0.070
AJCC pT category				0.996
pT3 vs pT2	1.707 (1.093-2.666)	0.019	1.019 (0.604-1.718)	0.943
pT4a vs pT2	2.405 (1.582-3.656)	0.000	1.024 (0.614-1.707)	0.927
AJCC pN category				0.000
pN1 vs pN0	1.758 (1.110-2.783)	0.016	1.487 (0.878-2.517)	0.140
pN2 vs pN0	2.996 (1.995-4.500)	0.000	2.501 (1.567-3.990)	0.000
pN3a vs pN0	4.531 (3.034-6.765)	0.000	3.406 (2.106-5.509)	0.000
pN3b vs pN0	6.377 (4.240-9.592)	0.000	4.245 (2.551-7.064)	0.000
Resection type
Total vs Proximal	1.772 (1.279-2.456)	0.001	1.103 (0.773-1.578)	0.590
Combined other organ resection
Yes vs No	1.579 (1.109-2.248)	0.011	1.189 (0.812-1.740)	0.374
LBVI
Positive vs Negative	1.750 (1.387-2.207)	0.000	1.200 (0.910-1.583)	0.197
Borrmann classification				0.019
Bor III vs Bor I-II	2.016 (1.321-3.077)	0.001	1.273 (0.807-2.006)	0.299
Bor IV vs Bor I-II	3.686 (2.295-5.922)	0.000	1.935 (1.131-3.311)	0.016

¹Adjacent organs invaded were diagnosed by the surgeon intraoperatively.