TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer

doi:10.4251/wjgo.v11.i7.551

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World Journal of Gastrointestinal Oncology

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2019; 11(7): 551-566
Published online Jul 15, 2019. doi: 10.4251/wjgo.v11.i7.551

Table 3 Frequency of TYMS 5’UTR, 3’UTR genotypes

Genotype	Total n (%)
TYMS 5’UTR	130 (100)
2R	13 (10.0)
2R/3R	78 (60.0)
2R/3RG	34 (26.1)
2R/3RG	20 (15.4)
2R/3RGLOH	8 (6.2)
2RLOH/3RG	6 (4.6)
2R/3RC	44 (33.8)
2R/3RC	24 (18.5)
2R/3RCLOH	13 (10.0)
2RLOH/3RC	7 (5.4)
3R	39 (30.0)
3RG	10 (7.7)
3RG/3RC	20 (15.4)
3RC	9 (6.9)

TYMS 3’UTR	130 (100)
ins/ins	28 (21.5)
ins/LOH	27 (20.8)
ins/del	52 (40.0)
del/LOH	7 (5.4)
del/del	16 (12.3)

TYMS: Thymidylate synthase gene; UTR: Untranslated region; SNP: Single nucleotide polymorphism; LOH: Loss of heterozygosity.

Citation: Ntavatzikos A, Spathis A, Patapis P, Machairas N, Vourli G, Peros G, Papadopoulos I, Panayiotides I, Koumarianou A. TYMS/KRAS/BRAF molecular profiling predicts survival following adjuvant chemotherapy in colorectal cancer. World J Gastrointest Oncol 2019; 11(7): 551-566
URL: https://www.wjgnet.com/1948-5204/full/v11/i7/551.htm
DOI: https://dx.doi.org/10.4251/wjgo.v11.i7.551