Role of circular RNAs in gastric cancer: Recent advances and prospects

Table 1 Deregulated circRNA in gastric cancer: function and potential signaling pathway

circRNA	Deregulation	Function/clinical association	Gene/pathway affected	Ref.
hsa_circ_0000993	Downregulation	Inhibits proliferation, migration and invasion	miR-214-5p	[23]
has_circ_0001461	Downregulation	Inhibits proliferation, migration and invasion; correlates with the clinical stage	miR-548g, RUNX1 in the cytoplasm; YBX1 in the nucleus	[24]
has_circ_0002320	Downregulation	Inhibits proliferation and invasion; correlates with TMN stage and survival time	miR-367-5p, p27	[25]
hsa_circ_0027599	Downregulation	Inhibits proliferation and migration; correlates with TNM stage	miR-101, PHLDA1	[26]
circRNA_100269	Downregulation	Inhibits proliferation; correlates with histological subtype,node invasive number and overall survival time	miR-630	[30]
circRNA_101057	Downregulation	Inhibits proliferation and invasion; correlates with tumor size and lymphatic metastasis and overall survival time	miR-424, LATS1	[31]
circZFR	Downregulation	Inhibits proliferation and promotes apoptosis	miR-130a/miR-107, PTEN	[35]
hsa_circ_0017639	Upregulation	Promotes proliferation; correlates with TNM stage	miR-182-5p, CREB1	[38]
circRNA_0000284	Upregulation	Promotes proliferation; correlates with T stage	miR-124 and miR-29b, COL1A1, COL4A1 and CDK6	[42]
circRNA_001569	Upregulation	Promotes proliferation and inhibits apoptosis; correlates with tumor size, depth of invasion and clinical stage	miR-145, NR4A2	[44]
circPDSS1	Upregulation	Promotes proliferation and inhibits apoptosis;correlates with worse overall survival time	miR-186-5p, NEK2	[45]
circNF1	Upregulation	Promotes proliferation	miR-16, MAP7 and AKT3	[49]
ciRS-7	Upregulation	Promotes proliferation and inhibits apoptosis; correlates with TNM stage and poor overall survival time	miR-7, PTEN/PI3K/AKT pathway	[53]

RUNX1: Runt-related transcription factor 1; YBX1: Y-box binding protein-1; PHLDA1: Pleckstrin homology like domain family A member 1; LATS1: Large tumor suppressor kinase 1; PTEN: Phosphatase and tensin homolog; CREB1: cAMP response element binding protein 1; COL1A1: Collagen type I α1 chain; COL4A1: Collagen type IV α1 chain; CDK6: Cyclin-dependent kinase 6; NR4A2: Nuclear receptor subfamily 4 group A member 2; NEK2: NIMA related kinase 2; MAP7: Microtubule associated protein 7.