Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways

Figure 5 Effects of QFGs on the expression of survivin, cyclin D1, CDK4, p21, Bax, Bcl-2, Fas, and FasL in HCT-116 and HCT-8 cells. A, B: The expression levels of survivin, cyclin D1, CDK4, and p21 were determined by western blot. β-actin was used as an internal control. Each band is representative of triplicate experiments. The band densities of western blots were quantitatively analyzed; C, D: The expressions of Bax, Bcl-2, Fas, and FasL were determined by western blot. β-actin was used as an internal control. Each band is representative of triplicate experiments. The band densities of western blots were quantitatively analyzed. ^aP < 0.05, ^bP < 0.01 vs the control group. QFGs: Qingjie Fuzheng granules; CDK4: Cyclin-dependent kinase 4; Bcl-2: B cell leukemia/lymphoma 2; Bax: Bcl2 associated X; FasL: Fas ligand.