Identification of genomic features associated with immunotherapy response in gastrointestinal cancers

Figure 1 Association between mismatch repair deficiency/microsatellite instability and tumor immunity in gastrointestinal cancers. A: Immune signatures are upregulated in the microsatellite instability-high (MSI-H) colon adenocarcinoma (COAD) vs the MSI low (MSI-L)/microsatellite stability (MSS) COAD (Mann-Whitney U test, P < 0.05); B: Immune signatures are upregulated in the MSI-H stomach adenocarcinoma (STAD) vs the MSI-L/MSS STAD. dMMR: Mismatch repair deficiency; MSI: Microsatellite instability; MSI-H: Microsatellite instability-high; MSI-L: Microsatellite instability-low; MSS: Microsatellite stability. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, MSI-H vs MSI-L/MSS. HLA: Human leukocyte antigen; IFN: Interferon; NK: Natural killer.