Risk of cholangiocarcinoma in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography or cholecystectomy: A population based study

Table 3 Incidence of cholangiocarcinoma amount patient with cholelithiasis underwent therapeutic endoscopic retrograde cholangiopancreatography, cholecystectomy or no intervention compared with normal population (excluding cholangiocarcinoma in the initial 6 mo)

Variables	Person-years at risk in study cohort	Person-years at risk in control cohort	No. of observed cases of cholangiocarcinoma in study cohort	No. of observed cases of cholangiocarcinoma in control cohort	Incidence rate/1000 person-years (95%CI) in study cohort	Incidence rate/1000 person-years (95%CI) in control cohort
ES/EPBD
Total	2519.33	125339.21	11	35	4.37 (2.30-7.59)	0.28 (0.20-0.38)
Gender
Male	1252.12	59176.6	3	20	2.40 (0.61-6.52)	0.34 (0.21-0.51)
Female	1267.21	66162.61	8	15	6.31 (2.93-11.99)	0.23 (0.13-0.37)
Age, yr
18-49	561.74	37789.95	1	5	1.78 (0.09-8.78)	0.13 (0.05-0.29)
50-69	895.32	48272.57	2	14	2.23 (0.38-7.38)	0.29 (0.17-0.48)
> 70	1062.27	39276.69	8	16	7.53 (3.50-14.30)	0.41 (0.24-0.65)
Cholecystectomy
Total	8911.32	125339.21	7	35	0.79 (0.34-1.55)	0.28 (0.20-0.38)
Gender
Male	4187.56	59176.6	3	20	0.72 (0.18-1.95)	0.34 (0.21-0.51)
Female	4723.76	66162.61	4	15	0.85 (0.27-2.04)	0.23 (0.13-0.37)
Age, yr
18-49	3173.23	37789.95	1	5	0.32 (0.02-1.55)	0.13 (0.05-0.29)
50-69	3413.76	48272.57	1	14	0.29 (0.01-1.45)	0.29 (0.17-0.48)
> 70	2324.33	39276.69	5	16	2.15 (0.79-4.77)	0.41 (0.24-0.65)
Cholelithiasis without intervention
Total	26820.41	125339.21	37	35	1.38 (0.99-1.88)	0.28 (0.20-0.38)
Gender
Male	12201.3	59176.6	21	20	1.72 (1.09-2.59)	0.34 (0.21-0.51)
Female	14619.11	66162.61	16	15	1.09 (0.65-1.74)	0.23 (0.13-0.37)
Age, yr
18-49	8423.77	37789.95	4	5	0.48 (0.15-1.15)	0.13 (0.05-0.29)
50-69	10889.04	48272.57	12	14	1.10 (0.60-1.87)	0.29 (0.17-0.48)
> 70	7507.6	39276.69	21	16	2.80 (1.78-4.20)	0.41 (0.24-0.65)

ES/EPBD: Endoscopic sphincterotomy/endoscopic papillary balloon dilatation.