Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis

doi:10.4251/wjgo.v11.i3.181

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Mar 15, 2019; 11(3): 181-194
Published online Mar 15, 2019. doi: 10.4251/wjgo.v11.i3.181

Table 2 Compound list (n = 32) of the significant changes between tumor and normal group using electrospray ionization positive and negative modes

Catalog	Putative ID	RT (min)	m/z	Adduct ion	VIP	FC
TG	TG(54:3)	15.6	902.8202	[M+NH₄]⁺	2.3	0.5
	TG(52:4)	15.1	872.7729	[M+NH₄]⁺	3.2	0.4
	TG(52:2)	15.6	876.8048	[M+NH₄]⁺	3.2	0.5
	TG(50:3)	15.0	846.7568	[M+NH₄]⁺	2.9	0.3
	TG(50:2)	15.3	848.7722	[M+NH₄]⁺	3.3	0.4
SM	SM(d18:1/24:0)	13.3	815.7015	[M+H]⁺	1.6	1.3
	SM(d18:1/18:0)	7.1	775.5980	[M+FA-H]^-	1.7	0.7
	SM(d18:0/22:0)	9.9	811.6627	[M+H]⁺	2.1	1.3
	SM(d18:0/16:0)	6.0	705.5912	[M+H]⁺	1.0	1.4
PS	PS(P-18:0/22:6)	9.2	818.5336	[M-H]^-	1.0	0.7
PI	PI(22:3/16:0)	6.1	887.5682	[M-H]^-	1.4	1.9
	PI(20:4/16:0)	4.2	857.5202	[M-H]^-	1.4	0.6
	PI(16:0/18:2)	4.4	833.520	[M-H]^-	3.0	0.8
PE	PE(P-18:1/20:4)	7.1	748.5279	[M-H]^-	2.5	0.7
	PE(P-18:0/18:2)	9.7	726.5437	[M-H]^-	2.5	1.7
	PE(P-16:0/18:2)	7.3	698.5117	[M-H]^-	4.0	1.9
	PE(20:4/16:0)	6.2	740.5237	[M+H]⁺	3.6	0.4
	PE(18:2/18:1)	6.6	740.5221	[M-H]^-	2.3	0.4
	PE(18:2/16:0)	6.4	714.5061	[M-H]^-	2.2	0.4
	PE(18:1/18:1)	8.2	742.5385	[M-H]^-	2.4	0.6
PC	PC(38:4)	6.4	810.6034	[M+H]⁺	2.6	1.7
	PC(34:3)	4.8	756.5561	[M+H]⁺	14.2	1.5
	PC(30:0)	5.5	706.5394	[M+H]⁺	2.9	2.4
	PC(18:2/16:0)	6.0	758.5702	[M+H]⁺	3.0	0.6
	PC(18:0/20:3)	8.6	812.6191	[M+H]⁺	3.3	3.6
	PC(18:0/18:1)	9.8	832.6090	[M+FA-H]^-	7.9	1.3
	PC (16:1/16:0)	5.6	776.5467	[M+FA-H]^-	1.2	2.0
	PC (16:0/16:0)	7.3	734.5717	[M+H]⁺	1.5	1.4
LysoPC	LysoPC (16:0)	1.2	496.3395	[M+H]⁺	3.1	0.7
Ceramide	Cer (d18:1/24:0)	13.9	694.6341	[M+FA-H]^-	1.6	1.6
carnitine	Linoleyl carnitine (C18:2)	1.0	424.3408	[M+H]⁺	1.2	0.6
carnitine	Oleoyl carnitine (C18:1)	1.2	426.3560	[M+H]⁺	1.1	0.8

All P value < 0.05. The protonated [M+H]⁺ and anionized adduct [M+NH₄]⁺ in positive mode, and deprotonated [M-H]^- and formic acid adduct [M+FA-H]^- in negative ion mode. FC: Fold changes (tumor/normal); LyPC: Lysophosphocholine; PC: Phosphocholine; PE: Phosphatidylethanolamine; SM: Sphingomyelin; PI: Phosphoinositol; TG: Triglyceride; VIP: Variable importance in projection.

Citation: Hung CY, Yeh TS, Tsai CK, Wu RC, Lai YC, Chiang MH, Lu KY, Lin CN, Cheng ML, Lin G. Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis. World J Gastrointest Oncol 2019; 11(3): 181-194
URL: https://www.wjgnet.com/1948-5204/full/v11/i3/181.htm
DOI: https://dx.doi.org/10.4251/wjgo.v11.i3.181