Redox, immune and genetic biomarker system for personalized treatments in colorectal cancer

Figure 7 The unbalance of Trx1/CD3 is a biomarker of inactive natural killer cells. A, B: Interactions between the levels of Trx1, RTrx1, sCD30 and immunological parameters with the CD3^-CD56⁺ and CD8^-CD57⁺ phenotypic markers, together with the age and the stage, in healthy subjects (A) and in patients (B), respectively. The chance of a healthy longevity for the elderly group is primarily determined by the homeostasis of the immune system redox regulation, in particular of sCD30, Trx1 and RTrx1; C: The most significant correlation of the subjects in the youngest class (“< 46”) is with the homeostasis of the redox immune response; D: The probability of a healthy longevity for the elderly group is primarily determined by the homeostasis of the immune system redox regulation, also when there are increased levels of IL6 [“> 89” and “< 46” vectors are closely related to each other and also with the RTrx1, Trx1 and sCD30 vectors (D)]. Vector colors: The same color identifies a functional outline explained in the text.