Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Table 6 Univariate analysis exploring risk-factors predictive of meeting European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer[24] criteria

		Patients who did not meet criteria for referral (n = 194)		Patients who did meet criteria for referral (n = 98)		Univariate analysis
		Frequency	Relative percentage	Frequency	Relative percentage	P value
Personal past medical history
Smoker (active or ex-smoker)	Yes	108	55.7	55	56.1	0.941
	No	86	44.3	43	43.9
Active smoker	Yes	45	23.2	16	16.3	0.173
	No	149	76.8	82	83.7
Alcohol consumption	Yes	131	70.8	75	83.3	0.025
	No	54	29.2	15	16.7
“Excess” alcohol consumption	Yes	24	12.9	5	5.6	0.060
	No	161	87.0	85	94.4
Previous pancreatitis	Yes	7	3.2	1	0.9	0.195
	No	213	96.8	112	99.1
Pancreatitis diagnosed > 2 yr before PDAC	Yes	5	2.3	0	0	0.3493
	No	2159	97.7	113	100
Past medical history of IPMN	Yes	0	0	0	0	n/a
	No	220	100	113	100
Type 2 diabetes mellitus	Yes	61	27.7	27	23.9	0.453
	No	156	72.3	86	76.1
Type 2 diabetes mellitus diagnosed > 2 yr before PDAC	Yes	22	11.0	11	10.6	0.910
	No	178	89.0	93	89.4
Type 1 diabetes mellitus	Yes	2	0.9	3	2.7	0.215
	No	218	99.1	110	97.4
Family past medical history
Any family history of cancer	Yes	93	42.1	109	96.5	< 0.0001
	No	128	57.9	4	3.5

Please note that patients for whom data regarding the variable analysed in this table was missing has been omitted for this analysis. IPMN: Intraductal Papillary Mucinous Neoplasm; PDAC: Pancreatic ductal adenocarcinoma.