Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Table 5 Univariate analysis exploring demographic characteristics as factors predictive of meeting European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer criteria

		Patients who did not meet criteria for referral (n = 221)		Patients who did meet criteria for referral (n = 113)		Univariate analysis
		Frequency	Relative percentage	Frequency	Relative percentage	P value
Demographic characteristics
Gender	Male	120	54.3	48	42.5	0.0041
	Female	101	45.7	65	57.5
Age (yr)	Mean (95%CI)	66.3 (64.9-67.7)		67.2 (65.4-68.9)		0.4726
Comorbidity grade (ACE-27)[34]	None	75	33.9	45	39.8	0.040
	Mild	97	43.9	39	34.5
	Moderate	28	12.7	24	21.2
	Severe	21	9.5	4	4.4
Pathological confirmation of malignancy	Yes	194	87.8	102	90.3	0.499
	No	27	12.2	11	9.7
Stage	Localised	4	1.8	0	0	0.015
	Locally advanced	120	54.3	46	40.7
	Metastatic	97	43.9	67	59.3
ECOG performance status	0	21	9.45	14	12.4	0.534
	1	107	48.4	58	51.3
	2	60	27.2	25	22.1
	3	32	14.5	14	12.4
	4	1	0.5	2	1.8
Treatment characteristics
Treatment intent	Curative	38	17.2	9	7.9	0.022
	Palliative	183	82.8	104	92.0
Curative surgery	Yes	38	17.2	13	11.5	0.171
	No	183	82.8	100	88.5
Adjuvant chemotherapy	Yes	23	10.4	9	7.9	0.465
	No	197	89.6	104	92.0
Palliative chemotherapy	Yes	125	56.6	65	57.5	0.867
	No	96	43.4	48	42.5

ACE-27: Adult Co-morbidity Evaluation- 27; ECOG: Eastern Cooperative Oncology Group; 95%CI: 95% confidence interval.