Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Table 4 Entire patient population family history of malignancy and whether European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer referral criteria were met

Risk Factor		Frequency	Relative percentage (%)
Any personal1/family history of cancer	Yes	202	50.5
	No	132	33.0
	Unknown	66	16.5
Any personal1 or family history of cancer meeting EUROPAC[24] criteria	Yes	113	28.3
	No	221	55.2
	Unknown	66	16.5
Criteria met	Criterion 1 (≥ 2 first-degree relatives with pancreatic cancer)	10	8.8
	Criterion 3.a (Personal/family history (≥ 1 first/second-degree relatives) of breast/ovarian cancer)	60	53.1
	Criterion 3.b [Personal/family history of melanoma in ≥ 1 first/second degree relative AND a high total body naevi count (often > 50)]	2	1.8
	Criterion 3.c [Personal/family history (≥ 1 first/second-degree relatives) of a Lynch syndrome-associated cancer (such as colorectal, endometrial, small bowel, renal)]	29	25.7
	Criterion 3.d (Oral/mucous membrane pigmentation +/- a personal/family history (≥ 1 first/second-degree relatives) of gastrointestinal cancers in first/second degree relatives)	12	10.6

¹In addition to the diagnosis of PDAC. EUROPAC: The European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer.