Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice

Table 1 European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer criteria[24]

EUROPAC criteria
Criterion 1	≥ 2 first-degree relatives with pancreatic cancer
Criterion 2	≥ 3 relatives with pancreatic cancer
Criterion 3	Possible associated cancer syndrome (defined as sub-criteria below) in addition to the case of pancreatic cancer being studied
Criterion 3.a: BRCA1/2	Personal/family history (≥ 1 first/second-degree relatives) of breast/ovarian cancer
Criterion 3.b: Familial Atypical Multiple Mole Melanoma (FAMMM) syndrome	Personal/family history of melanoma in ≥ 1 first/second degree relative AND a high total body naevi count (often > 50)
Criterion 3.c: Lynch syndrome	Personal/family history (≥ 1 first/second-degree relatives) of a Lynch syndrome-associated cancer (such as colorectal, endometrial, small bowel, renal)
Criterion 3.d: Peutz-Jeghers syndrome	Oral/mucous membrane pigmentation +/- a personal/family history (≥ 1 first/second-degree relatives) of gastrointestinal cancers in first/second degree relatives

EUROPAC: European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer.