Analysis of factors potentially predicting prognosis of colorectal cancer

Table 1 Comparison of indicators between the good prognosis group and poor prognosis group before treatment

	Good prognosis group (n = 274)	Poor prognosis group (n = 81)	t/χ2 value	P value
Age	53.64 ± 15.38	60.47 ± 8.34	3.831	0.000
Gender (Male/Female)	143/131	43/38	0.020	0.887
BMI (kg/m2)	26.49 ± 5.34	25.39 ± 5.91	1.589	0.113
Smoking [n (%)]	74 (27.01%)	24 (29.63%)	0.215	0.643
History of alcohol abuse [n (%)]	39 (14.23%)	13 (16.05%)	0.165	0.685
Family history [n (%)]	46 (16.79%)	20 (24.69%)	2.580	0.108
Tumor diameter (cm)	2.08 ± 1.47	5.69 ± 2.54	16.125	0.000
Tumor location
Ascending colon [n (%)]	39	13	3.139	0.535
Transverse colon [n (%)]	14	7
Lower colon [n (%)]	25	10
Sigmoid colon [n (%)]	84	22
Rectum [n (%)]	112	29
Tumor histology type
Adenocarcinoma	177	53	0.019	0.890
Mucinous adenocarcinoma and signet ring cell carcinoma	97	28
TNM stage
I	10 (3.65%)	6 (7.41%)	29.292	0.000
II	213 (77.74%)	38 (46.91%)
III	30 (10.95%)	24 (29.63%)
IV	21 (7.66%)	13 (16.05%)
Dukes stage
A	17 (6.20%)	1 (1.23%)		0.062
B	177 (64.60%)	48 (59.26%)
C	80 (29.20%)	32 (39.51%)
PCNA
1	98	4	114.291	0.000
2	122	11
3	45	43
4	9	23
P53
-	34	11	4.908	0.297
+	64	14
++	61	17
+++	78	23
++++	37	19
GPS
0	233 (85.04%)	9 (11.11%)	157.579	0.000
1	24 (8.76%)	40 (49.38%)
2	17 (6.20%)	32 (39.51%)
C-reactive protein (mg/L)	2.73 ± 0.64	21.83 ± 16.34	19.364	0.000
Albumin (g/L)	42.43 ± 7.93	33.74 ± 6.21	9.071	0.000
WBC count (9 × 103/mm3)	5.89 ± 1.98	8.53 ± 2.83	9.481	0.000
Platelet count (9 × 104/mm3)	237.43 ± 103.28	247.23 ± 116.39	0.728	0.467
NLR	2.68 ± 1.73	4.53 ± 3.29	6.699	0.000
CAR	0.089 ± 0.017	0.175 ± 0.092	14.693	0.000
D-dimer (μg/mL)	0.553 ± 0.207	0.943 ± 0.375	13.117	0.000
Fibrinogen (g/L)	3.121 ± 1.542	3.524 ± 1.053	2.204	0.028
CEA (ng/mL)	3.34 ± 1.82	6.13 ± 2.36	11.281	0.000
CA199 (U/mL)	186.82 ± 139.74	635.24 ± 284.38	15.067	0.000

BMI: Body mass index; TNM: Tumor-node-metastasis; PCNA: Proliferating cell nuclear antigen; GPS: Glasgow prognostic score; WBC: White blood cell; NLR: Neutrophil-lymphocyte ratio; CAR: C-reactive protein/albumin ratio; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199.