Clinical significance of MLH1/MSH2 for stage II/III sporadic colorectal cancer

Figure 3 Analysis of microsatellite instability in colorectal cancer tissues and corresponding normal mucosa using the five markers of the international workshop of Bethesda and fluorescence-based multiplex polymerase chain reaction. Fragment pattern of a high-frequency microsatellite instability tumor showing instability at all five loci examined is shown. A: Low microsatellite instability (MSI-L) of tumor tissue; B: MSI-L of corresponding normal tissue; C: High microsatellite instability (MSI-H) of tumor tissue; D: MSI-H of corresponding normal tissue; E: Microsatellite stability (MSS) of tumor tissue; F: MSS of corresponding normal tissue.