Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population.

doi:10.4251/wjgo.v11.i11.998

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Nov 15, 2019; 11(11): 998-1010
Published online Nov 15, 2019. doi: 10.4251/wjgo.v11.i11.998

Table 6 TLR9 gene expression levels of GC and CG groups to assess influence of polymorphic genotypes

Groups		TLR9-1237T/C (rs5743836)		P value	TLR9-1486 C/T (rs187084)		P value
		TT	TC/CC		CC	CT / TT
		Upregulated cases			Upregulated cases
GC (n = 26)	Median	5.24	13.01	0.0083	7.37	9.90	0.8763
GC (n = 26)	Range	1.72-9.27	7.55-189.00	0.0083	5.74-14.16	2.49-53-75	0.8763
CG (n = 48)	Median	1.47	1.45	0.8442	3.26	1.50	0.1515
CG (n = 48)	Range	0.77-4.19	0.75-3.82	0.8442	1.39-8.46	0.75-3.00	0.1515

GC: Gastric cancer; CG: Chronic gastritis.

Citation: Susi MD, Lourenço Caroline M, Rasmussen LT, Payão SLM, Rossi AFT, Silva AE, Oliveira-Cucolo JG. Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population.. World J Gastrointest Oncol 2019; 11(11): 998-1010
URL: https://www.wjgnet.com/1948-5204/full/v11/i11/998.htm
DOI: https://dx.doi.org/10.4251/wjgo.v11.i11.998