Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population.

Table 3 Haplotype frequency distribution of TLR9 polymorphisms between GC, CG and control groups

Haplotypes	GC, %	C, %	X2	P value	CG, %	C, %	X2	P value	GC, %	CG, %	X2	P value
TLR9-1237/-1486
T-C	35.2	47.7	38.284	≤ 0.0001	40.5	48.4	5.617	0.0178	24.9	39.7	19.098	≤ 0.0001
T-T	36.9	36.3	0.024	0.8772	44.2	35.6	6.778	0.0092	37.3	45.0	4.838	0.0278
C-T	18.7	8.2	17.656	≤ 0.0001	9.8	8.9	0.233	0.6290	18.3	9.0	15.335	≤ 0.0001
C-C	19.2	7.8	20.475	≤ 0.0001	5.5	7.1	1.000	0.3158	19.6	6.3	33.560	≤ 0.0001

C: Control; GC: Gastric cancer; CG: Chronic gastritis.