Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population.

Table 2 Genotype and allele frequencies of TLR9-1237 T/C and TLR9-1486 C/T SNPs in both case and control groups (GC vs C, CG vs C, and GC vs CG)

Polymorp-hisms	Models	Genotypes/ Alleles	C, n = 200	Cases
				GC, n = 161	OR (95%CI), P value		CG, n = 248	OR (95%CI), P value
TLR9-1237 T/C (rs5743836)	Dominant	TT	148 (74%)	78 (48.5%)	1.00		188 (75.8%)	1.00
		TC + CC	52 (26%)	83 (51.5%)	3.03 (1.95-4.71), < 0.0001		60 (24.2%)	0.91 (0.59-1.40), 0.6600
	Recessive	TT + TC	188 (94%)	122 (75.8%)	1.00		232 (93.5%)	1.00
		CC	12 (6%)	39 (24.2%)	5.01 (2.52-9.94), < 0.0001		16 (6.5%)	1.08 (0.50-2.34), 0.8400
	Log-additive				2.37 (1.74-3.23), < 0.0001			0.96 (0.70-1.32), 0.8100
	Alleles	T	336 (0.84)	200 (0.62)	1.00		420 (0.85)	1.00
		C	64 (0.16)	122 (0.38)	3.20 (2.25-4.54), < 0.0001		76 (0.15)	0.95 (0.66-1.36), 0.7822
GC vs CG	Dominant			3.46 (2.23-5.37), < 0.0001
OR (95%CI), P	Recessive			4.63 (2.44-8.79), < 0.0001
	Log-additive			2.46 (1.82-3.34), < 0.0001
	Alleles			3.37 (2.41-4.70), < 0.0001
TLR9-1486 C/T (rs187084)	Dominant	CC	58 (29%)	21 (13%)		1.00	46 (18.6%)	1.00
		CT + TT	142 (71%)	140 (87%)		2.72 (1.57-4.72), < 0.0001	202 (81.5%)	1.79 (1.15-2.79), 0.0094
	Recessive	CC + CT	164 (82%)	122 (75.8%)		1.00	182 (73.4%)	1.00
		TT	36 (18%)	39 (24.2%)		1.46 (0.87-2.43), 0.1500	66 (26.6%)	1.65 (1.05-2.61), 0.0300
	Log-additive					1.70 (1.23-2.37), 0.0013		1.52 (1.15-2.02), 0.0030
	Alleles	C	222 (0.56)	143 (0.44)		1.00	228 (0.46)	1.00
		T	178 (0.44)	179 (0.56)		1.56 (1.16-2.09), 0.0035	268 (0.54)	1.46 (1.12-1.91), 0.0048
GC vs CG	Dominant			1.15 (0.72-1.84), 0.5700
OR (95%CI), P	Recessive			0.69 (0.39-1.24), 0.2100
	Log-additive			0.95 (0.69-1.31), 0.7500
	Alleles			0.93 (0.70-1.24), 0.6670

C: Control; OR: Odds ratio; CI: Confidence interval; GC: Gastric cancer; CG: Chronic gastritis.