Non-coding RNA in drug resistance of gastric cancer

Table 4 Summary of other miRNAs involved in single drug resistance in gastric cancer

Drugs	miRNA	Pathway/target	Dysregulation	Ref.
DDP	miR-193a-3p	CD44, SRSF2, Bcl-X, Bcl-2, caspase 9	Up-regulated	[80]
DDP	miR-214	PARP9, CD81, XRCC1, LIN28B	Up-regulated	[81]
DDP	miR-25	FOXO3a, p27Kip1	Up-regulated	[82]
DDP	miR-132	SIRT1, CREB, ABCG2	Up-regulated	[83]
DDP	miR-99a	CAPNS1, calpain1, calpain2, Caspase3, PARP1	Up-regulated	[84]
	miR-491
DDP	miR-421	HIF-1α, Snail, cleaved caspase-3, cleaved PARP, E-cadherin, N-cadherin, Fibronectin, Vimentin	Up-regulated	[85]
DDP	miR-493	DKK1	Up-regulated	[86]
DDP	miR-141	KEAP1	Up-regulated	[87]
DDP	miR-223	FBXW7, CCND1/2/3, CCNE1/2, CCNE2, CDK2/4/6, p14, p16, p21, p27, c-Myc	Up-regulated	[88,89]
Trastuzumab
DDP	miR-604	POLR2L, POLR2C, APRT, LMAN2	Down-regulated	[90]
DDP	miR-17-5p	E2F1, p21, MCL1	Down-regulated	[91]
DDP	miR-125b	HER2	Down-regulated	[92]
DDP	miR-320a	ADAM10	Down-regulated	[93]
DDP	miR-148a-3p	AKAP1, RAB12, DRP1	Down-regulated	[94]
DDP	miR-200c	ZEB2	Down-regulated	[95]
DDP	miR-524-5p	SOX9	Down-regulated	[96]
DDP	miR-149	FoxM1	Down-regulated	[97]
DDP	miR-203	Cleaved caspase-3/9, Bcl-w	Down-regulated	[98]
DDP	miR-29b	AKT2, PI3K/Akt	Down-regulated	[99]
DDP	miR-26a	NRAS, E2F2	Down-regulated	[100]
DDP	miR-143	IGF1R, Bcl2	Down-regulated	[101]
DDP	miR-503	IGF1R, Bcl2	Down-regulated	[102]
DDP	miR-1271	IGF1R/IRS1, mTOR, Bcl2	Down-regulated	[103]
DDP	miR-22	ENO1	Down-regulated	[105]
DDP/PTX	miR-181a	Autophagy, AKT/ERK	Down-regulated	[46,104]
5-Fu	miR-193-3p	PTEN	Up-regulated	[106]
5-Fu	miR-204	TGFBR2, Induced EMT, TGF-β	Down-regulated	[107]
5-Fu	miR-31	RhoA	Down-regulated	[108]
5-Fu	miR-939	SLC34A2, Raf/MEK/ERK	Down-regulated	[109]
5-Fu	miR-BART15-3p	TAX1BP1, NF-ƙB	Down-regulated	[110]
5-Fu	miR-197	MAPK1	Down-regulated	[111]
5-Fu	miR-BART20-5p	BAD	Down-regulated	[112]
PTX	miR-3127-5p/miR-1287/miR-4713-5p	AKT/ERK	Up-regulated	[113]
PTX	miR-224/miR-452/miR-424/miR-130a/miR-193b	AKT/ERK	Down-regulated	[113]
Docetaxel	let-7a	HMGA2	Up-regulated	[114]
DOX	miR-140	SOX4, ABCC1, ABCG2	Down-regulated	[115]
VCR	miR-647	ANK2, FAK, MMP2, MMP12, CD44, SNAIL2	Down-regulated	[116]
OXA	miR-361	ABCB1, BLACAT1	Down-regulated	[35]
TRAIL	miR-942	ISG12a, AKT, ISG12a, Cleaved PARP	Up-regulated	[117]
Lapatinib	miR494	FGFR2	Down-regulated	[118]

DDP: Cisplatin; 5-Fu: 5-fluorouracil; PTX: Paclitaxel; DOX: Doxorubicin; VCR: Vincristine; OXA: Oxaliplatin; TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand.