Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

Table 1 The schedules of chemotherapy regimens

Oral fluoropyrimidine-based regimen1,3

Cetuximab + CAPOX every 3 wk

Cetuximab: 500 mg/m2 on day 1 and 250 mg/m2 on day 15

Oxaliplatin: 130 mg/m2 on day 1

Capecitabine: 1000 mg/m2 from day 1 to day 14

Cetuximab + CAPIRI every 3 wk

Cetuximab: 500 mg/m2 on day 1 and 250 mg/m2 on day 15

Irinotecan: 200 mg/m2 on day 1

Capecitabine: 800 mg/m2 from day 1 to day 14

Infusional fluoropyrimidine-based regimen2,3

Cetuximab + FOLFOX every 2 wk

Cetuximab: 500 mg/m2 on day 1

Oxaliplatin: 85 mg/ m2 on day 1

Leucovorin: 200 mg/m2 over 2 h on day 1 and 2

5-Fluorouracil: 400 mg/m2 bolus on day 1 and 2

5-Fluorouracil: 600 mg/m2 over 20 h on day 1 and 22 h on day 2

Cetuximab + FOLFIRI every 2 wk

Cetuximab: 500 mg/m2 on day 1

Irinotecan: 180 mg/ m2 on day 1

Leucovorin: 200 mg/m2 over 2 h on day 1 and 2

5-Fluorouracil: 400 mg/m2 bolus on day 1 and 2

5-Fluorouracil: 600 mg/m2 over 20 h on day 1 and 22 h on day 2

In brief, treatment has to be withheld for grade 2 or above toxicities and to be resumed once recovered to grade 1. Dose reduction was considered for recurrent grade 2, or grade 3 or above toxicities.

¹75% dose of the regimen would be used if patients were older than 70 years old and 75% dose of capecitabine if creatinine clearance was less than 50 mL/min;

²75% dose of the regimen would be used if patients were older than 70 years old;

³Dose modification of chemotherapy due to toxicities was performed according to standard practice.