Oral chemotherapy for second-line treatment in patients with gemcitabine-refractory advanced pancreatic cancer

Table 4 Toxicity profile during treatment

Adverse event n, (%)	Capecitabine (n = 41)		S-1 (n = 40)
	Any grade	Grade ≥ 3	Any grade	Grade ≥ 3	P value1
Nausea	11 (26.8)	1 (2.4)	13 (32.5)	1 (2.5)	1.000
Vomiting	4 (9.8)	1 (2.4)	5 (12.5)	0	1.000
Diarrhea	4 (9.8)	0	3 (7.5)	0
Stomatitis	7 (17.1)	0	6 (15.0)	1 (2.5)	0.494
Hand-foot syndrome	13 (31.7)	6 (14.6)	2 (5.0)	0	0.026
Anemia	12 (29.3)	0	9 (22.5)	0
Neutropenia	7 (17.1)	0	3 (7.5)	0

¹P value for grade ≥ 3 adverse events.