Abnormally expressed circular RNAs as novel non-invasive biomarkers for hepatocellular carcinoma: A meta-analysis

doi:10.4251/wjgo.v11.i10.909

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Gastrointest Oncol. Oct 15, 2019; 11(10): 909-924
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.909

Table 4 Associations between circular RNA expression and clinicopathological factors in patients with hepatocellular carcinoma

Class	Included studies	χ²	Pooled P-value
Gender	18	36.426	0.4487
Age	18	32.517	0.635
Smoking (yes vs no)	5	8.597	0.5707
Alcoholism	5	19.684	0.0323
Tumor size	13	57.979	0.00012
Tumor number (single vs multiple)	7	14.3614	0.4231
Encapsulation (incomplete/complete)	3	3.8078	0.7026
Differentiation grade (well/moderate/poor)	11	66.9698	1.97 × 10⁻⁶
Microvascular invasion	3	19.261	0.003744
TNM stage	13	76.1066	2.51 × 10⁻⁷
HBsAg	7	14.4284	0.418306
Serum AFP	12	42.4249	0.0115
Metastasis	12	79.8852	6.35 × 10⁻⁸
ALT	3	5.4896	0.4827
AST	4	12.3545	0.1361
GGT	3	14.3614	0.4231
Cirrhosis (yes/no)	5	5.8236	0.8298

ALT: Alanine transaminase; AST: Aspartate transaminase; GGT: Gamma-glutamyl transpeptidase; AFP: Alpha fetoprotein; TNM: Tumor-node-metastasis; HbsAg: Hepatitis B surface antigen.

Citation: Jiang YL, Shang MM, Dong SZ, Chang YC. Abnormally expressed circular RNAs as novel non-invasive biomarkers for hepatocellular carcinoma: A meta-analysis. World J Gastrointest Oncol 2019; 11(10): 909-924
URL: https://www.wjgnet.com/1948-5204/full/v11/i10/909.htm
DOI: https://dx.doi.org/10.4251/wjgo.v11.i10.909