Abnormally expressed circular RNAs as novel non-invasive biomarkers for hepatocellular carcinoma: A meta-analysis

Table 1 Characteristics of the included studies for diagnosis and clinicopathologic features

Study	Ethnicity	Patient size	Control size	Control source	Sample type	CircRNA Name	Expression status	Method	Cut-Off value	Control gene	AUC	QUADAS score
Fu et al[12], 2017	Chinese	107	107	CH & LC	Tissue	hsa_circ_0003570	Decreased	qRT-PCR	12.24	GAPDH	0.70	4
Yao et al[25], 2017	Chinese	102	102	Adjacent non-cancerous liver tissue	Tissue	circZKSCAN1	Decreased	qRT-PCR	Unclear	GAPDH	0.834	4
Shang et al[21], 2016	Chinese	30	30	Adjacent nontumorous tissue	Tissue	hsa_circ_0005075	Increased	qRT-PCR	0.000586	GAPDH	0.94	6
Qin et al[20], 2016	Chinese	89	89	Paired adjacent liver tissues	Tissue	Hsa_circ_0001649	Decreased	qRT-PCR	0.00079	β-actin	0.63	6
Chen et al[11], 2018	Chinese	30	30	Para-tumorous tissues	Tissue	hsa_circ_0091582	Increased	qRT-PCR	Unclear	GAPDH	0.679	5
Chen et al[11], 2018	Chinese	30	30	Para-tumorous tissues	Tissue	hsa_circ_0128298	Increased	qRT-PCR	Unclear	GAPDH	0.664	5
Chen et al[11], 2018	Chinese	48	48	Para-tumorous tissues	Tissue	hsa_circ_0128298	Increased	qRT-PCR	Unclear	GAPDH	0.668	5
Huang et al[17], 2017	Chinese	102	129	Para-tumorous and CH tissues	Tissue	hsa_circ_0004018	Decreased	qRT-PCR	0.531	GAPDH	0.848	5
Zhang et al[28],2018	Chinese	104	52	Healthy control	Plasma	hsa_circ_0001445	Decreased	qRT-PCR	Unclear	GAPDH	0.862	5
Zhang et al[29], 2018	Chinese	104	57	LC	Plasma	hsa_circ_0001445	Decreased	qRT-PCR	Unclear	GAPDH	0.672	5
Zhang et al[29], 2018	Chinese	104	44	CH	Plasma	hsa_circ_0001445	Decreased	qRT-PCR	Unclear	GAPDH	0.764	5
Han et al[16], 2017	Chinese	80	80	Non-cancer tissue	Tissue	CircRNA pattern	/	qRT-PCR	Unclear	Unclear	0.988	3
Han et al[16], 2017	Chinese	20	20	Non-cancer tissue	Tissue	CircRNA pattern	/	qRT-PCR	Unclear	Unclear	0.976	3

AUC: Area under the curve; circRNA: Circular RNA; CH: Chronic hepatitis; LC: Liver cirrhosis; qRT-PCR: Quantitative real-time PCR; GAPDH: Reduced glyceraldehyde-phosphate dehydrogenase; QUADAS: Quality Assessment for Studies of Diagnostic Accuracy.