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©The Author(s) 2019.
World J Gastrointest Oncol. Oct 15, 2019; 11(10): 887-897
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.887
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.887
Table 3 Profiles of acylcarnitine in non-steatohepatitis patients without and with hepatocellular carcinoma
| Variable | Patients without HCC (n = 19) | Patients with HCC (n = 14) | P value |
| Acetylcarnitine (AC2) | 3.96 (3.33–4.92) | 2.06 (1.335–2.255) | < 0.05 |
| Propionylcarnitine (AC3) | 0.339 (0.2875–0.4115) | 0.3375 (< 0.24–0.473) | NS |
| Butyrylcarnitine (AC4) | < 0.1 (< 0.1–0.1) | 0.0795 (< 0.1–0.196) | NS |
| Isovalerylcarnitine (AC5) | < 0.06 (< 0.06–0.1085) | < 0.06 (< 0.06–0.0787) | NS |
| Glutarylcarnitine (AC5DC) | < 0.05 (< 0.05–0.05) | < 0.05 (< 0.05–0.05) | NS |
| 3-hydroxy isovalerylcarnitine (AC5OH) | < 0.1 (< 0.1–0.1) | < 0.1 (< 0.1–0.1) | NS |
| Hexanoylcarnitine (AC6) | 0.0531 (< 0.05–0.0596) | < 0.05 (< 0.05–0.05) | < 0.05 |
| Octanoylcarnitine (AC8) | 0.176 (0.1425–0.2375) | 0.0871 (0.0622–0.11025) | < 0.05 |
| Decanoylcarnitine (AC10) | 0.335 (0.256–0.432) | 0.1315 (0.099675–0.171) | < 0.05 |
| Dodecanolycarnitine (AC12) | 0.105 (0.0849–0.1335) | 0.02725 (0–0.06195) | < 0.05 |
| Myristoylcarnitine (AC14) | < 0.06 (< 0.06–0.06) | < 0.06 (< 0.06–0.06) | NS |
| Myristoleylcarnitine (AC14:1) | 0.185 (0.134–0.2325) | 0.07825 (0.06305–0.09855) | < 0.05 |
| Palmitoylcarnitine (AC16) | 0.133 (0.1255–0.1485) | 0.116 (0.10425–0.1310) | NS |
| 3-hydroxy palmitoylcarnitine (AC16OH) | < 0.03 (< 0.03–0.03) | < 0.03 (< 0.0 –0.03) | NS |
| Octadecanoylcarnitine (AC18) | 0.0429 (0.03245–0.04775) | 0.03315 (0.006625–0.039525 | < 0.05 |
| Oleoylcarnitine (AC18:1) | 0.871 (0.6825–1.0350) | 0.721 (0.61275–0.83775) | NS |
| 3-hydroxy octadecenoylcarnitine (AC18:1OH) | < 0.025 (< 0.025–0.02615) | < 0.025 (< 0.025–0.025) | NS |
| Short-chain fatty acids (AC2–AC6) | 4.3362 (3.83995–5.561750) | 2.4316 (1.86085–2.994125) | < 0.05 |
| Medium-chain fatty acids (AC8 + AC10) | 0.50600 (0.40700–0.69100) | 0.21385 (0.16545–0.28075) | < 0.05 |
| Long-chain fatty acid (AC12–AC18:1OH) | 1.3668 (1.106550–1.5871) | 0.9425 (0.836625–1.1087) | < 0.05 |
- Citation: Takaya H, Namisaki T, Kitade M, Shimozato N, Kaji K, Tsuji Y, Nakanishi K, Noguchi R, Fujinaga Y, Sawada Y, Saikawa S, Sato S, Kawaratani H, Moriya K, Akahane T, Yoshiji H. Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients. World J Gastrointest Oncol 2019; 11(10): 887-897
- URL: https://www.wjgnet.com/1948-5204/full/v11/i10/887.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v11.i10.887