Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients

Table 2 Diagnostic accuracy of biomarkers for the early diagnosis of hepatocellular carcinoma

Variable	OR (95%CI)	P value
Univariate analysis
AFP > 10 ng/mL	1.67 (0.332-8.37)	0.535
DCP > 40 mAU/mL	8.00 (0.776-82.5)	0.0806
AFP-L3% > 5%	1.35 (0.999-1.84)	0.0221
VEGF > 60pg/mL	2.67 (0.630-1.3)	0.183
VEGFR-2 > 6500 pg/mL	2.83 (0.666-12.0)	0.159
Total carnitine (per 1 μmol/L increase)	0.979 (0.933-1.03)	0.380
Free carnitine (per 1 μmol/L increase)	0.991 (0.943-1.04)	0.710
Acylcarnitine (per 1 μmol/L increase)	0.0865 (0.0158-0.475)	0.0049
Multivariate analysis
Acylcarnitine (per 1 μmol/L increase)	0.0941 (0.00137-0.646)	0.0162

HCC: Hepatocellular carcinoma; AFP: α-Fetoprotein; DCP: Des-γ-carboxy prothrombin; AFP-L3%: Lens culinaris agglutinin-reactive α-fetoprotein; VEGF: Vascular endothelial growth factor; VEGFR-2: VEGF receptor-2; CI: Confidence interval; OR: Odds ratio.