Retrospective review of total neoadjuvant therapy

Table 2 Different surgery/chemoradiation protocols used per standard guidelines

Treatment type	Protocol used
nCRT	50-55Gy/25-28 fx with concurrent 5-fluorouracil (5-FU) or capecitabine1
Post-op MaChT	Excisional surgery followed by postoperative (i.e. adjuvant) chemotherapy with 5-FU based regimens1
TNT	25-35Gy/5 fx followed by CAPOX or FOLFOX chemotherapy

1nCRT and MaChT are usually used in conjunction with each other in traditional chemoradiation therapy. nCRT: Neoadjuvant chemoradiotherapy; MaChT: Multi-agent chemotherapy; TNT: Total neoadjuvant therapy.