Targeted agents for second-line treatment of advanced hepatocellular carcinoma

Table 3 Efficacy results of the CELESTIAL phase III trial

Outcome	Cabozantinib	Placebo	HR	P value
Intent to treat population	n = 470 (%)	n = 237 (%)	(95%CI)
Overall response rate				0.009
Partial response	18 (4)	1 (< 1)	-
95%CI	(2.3-6.0)	(0.0-2.3)
Stable disease	282 (60)	78 (33)	-	NR
Disease control rate	300 (64)	79 (33)	-	NR
Overall survival in mo
Median	10.2	8.0	0.76	0.005
95%CI	9.1-12.0	6.8-9.4	(0.63-0.92)
Progression-free survival in mo
Median	5.2	1.9	0.44	< 0.001
95%CI	4.0-5.5	1.9-1.9	(0.36-0.52)
Time to progression in mo				NR
Median	5.4	1.9	0.41
95%CI	(4.0-5.6)	(1.9-1.9)	(0.34-0.49)
Patients who have only received sorafenib as prior therapy	n = 335 (%)	n = 174 (%)	HR (95%CI)	P value
Overall survival in mo
Median	11.3	7.2	0.70	NR
95%CI	9.5-13.9	5.8-9.3	(0.55-0.88)
Progression-free survival in mo
Median	5.5	1.9	0.40	NR
95%CI	4.6-5.7	1.9-1.9	(0.32-0.50)

Adapted from: Abou-Alfa et al[34]; Merle et al[35]; Kelley et al[36]. CI: Confidence interval; NR: Not reported; HR: Hazard ratio.