Targeted agents for second-line treatment of advanced hepatocellular carcinoma

Table 1 Efficacy results of the RESORCE phase III trial

Outcome based on assessment per mRECIST	Regorafenib n = 379 (%)	Placebo n = 194 (%)	HR (95%CI)	P value
Response
Complete	2 (1)	0	-	NR
Partial	38 (10)	8 (4)	-	NR
Overall response rate	40 (11)	8 (4)	-	0.0047
Stable disease	206 (54)	62 (32)	-	NR
Disease control rate	247 (65)	70 (36)	-	< 0.0001
Overall survival in mo
Median	10.6	7.8	0.63	< 0.0001
95%CI	9.1-12.1	6.3-8.8	(0.50-0.79)
Progression-free survival in mo
Median	3.1	1.5	0.46	< 0.0001
95%CI	2.8-4.2	1.4-1.6	(0.37-0.56)
Time to progression in mo
Median	3.2	1.5	0.44	< 0.0001
95%CI	(2.9-4.2)	(1.4-1.6)	(0.36-0.55)
Outcome based on assessment per RECIST 1.1
Response
Complete	0	0	-	NR
Partial	25 (7)	5 (3)	-	NR
Overall response rate	25 (7)	5 (3)	-	0.02
Stable disease	223 (59)	62 (32)	-	NR
Disease control rate	249 (66)	67 (35)	-	< 0.0001
Progression-free survival in mo
Median	3.4	1.5	0.43	< 0.0001
95%CI	2.9-4.2	1.4-1.5	(0.35-0.52)
Time to progression in mo
Median	3.9	1.5	0.41	< 0.0001
95%CI	(2.9-4.2)	(1.4-1.6)	(0.34-0.51)

Adapted from: Bruix et al[14]; Bruix et al[18]. CI: Confidence interval; NR: Not reported; HR: Hazard ratio.