Albumin-to-alkaline phosphatase ratio: A novel prognostic index of overall survival in cholangiocarcinoma patients after surgery

Table 2 Univariate and multivariate analyses of factors in relation to overall survival

Variable	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age, yr	1.3 (0.6–2.1)	0.650
≥ 60
≥ 60
Sex	0. 98 (0.64-1.76)	0.300
Female
Male
Infectious diseases
HBV	1.85 (1.10-2.47)	P < 0.001	1.31 (1.42–1.92)	< 0.001
HCV	1.67 (0.23-12.03)	0.486
Serum albumin level, g/L	0.84 (0.59-1.21)	0.278
≥ 35
< 35
ALP, ng/mL	2.46 (0.98-6.18)	0.054
≥ 20
< 20
AAPR	3.56 (1.28-9.92)	0.035	2.88 (1.19-5.78)	0.002
≥ 0.41
< 0.41
Tumor size, cm	3.14 (1.80-6.05)	0.021	2.71 (1.72-4.79)	0.012
≥ 5
< 5
Number of tumors	2.82 (1.17-4.28)	0.013	2.30 (1.95-3.20)	< 0.001
≥ 2
1
Curative resection	0.49 (0.17-0.85)	0.007	0.35 (0.29-0.42)	0.001
Yes
No
Stage (III + IV)	2.02 (1.34–3.12)	< 0.001	1.81 (1.242.49)	< 0.001

HR: Hazard ratio; AAPR: Albumin-to-alkaline phosphatase ratio; HBV: Hepatitis B virus; HCV: Hepatitis C virus; CCA: Cholangiocarcinoma; ALP: Alkaline phosphatase.