Prognostic significance of primary tumor localization in stage II and III colon cancer

Table 4 Factors affecting overall survival

		Univariate analysis						Multivariate analysis
		HR	95%CI				P	HR		95%CI			P
Age (yr)	< 65	1						1
	≥ 65	4.136		2.731	6.263	< 0.001		4.049	2.578		6.358	< 0.001
Gender	Male	1
	Female	0.951		0.636	1.423	0.808
Family history	No	1
	Yes	0.306		0.043	2.196	0.239
Smoking status	No	1
	Yes	0.815		0.533	1.247	0.346
Alcohol using status	No	1
	Yes	0.348		0.086	1.411	0.139
Mode of surgery	Elective	1
	Emergent	1.342		0.812	2.219	0.252
DM	No	1
	Yes	1.683		0.953	2.972	0.073
HT	No	1
	Yes	3.067		2.035	4.623	< 0.001
Histology	Adenocarcinoma	1
	Mucinous adenocarcinoma	1.213		0.733	2.006	0.452
Tumor grade	Well and moderately	1
	Poorly	1.036		0.453	2.369	0.933
Tumor location	RCC	1
	LCC	0.807		0.539	1.208	0.297
Tumor stage	II	1						1
	III	2.363		1.57	3.557	< 0.001		1.723	1.037		2.863	0.036
pT stage	T1 + 2	1				< 0.001
	T2	4.836		1.526	15.326	0.007
	T4	21.34		6.162	73.897	< 0.001
Number of removed lymph nodes	≥ 12	1
	< 12	1.402		0.897	2.192	0.138
pN	N0	1				< 0.001
	N1	2.122		1.353	3.327	0.001
	N2	3.015		1.742	5.219	< 0.001
PNI	Negative	1						1
	Positive	3.653		2.4	5.562	< 0.001		2.198	1.374		3.517	0.001
LVI	Negative	1						1
	Positive	3.735		2.445	5.707	< 0.001		2.523	1.543		4.127	< 0.001
Surgical margin	Negative	1
	Positive	2.57		0.633	10.435	0.187
Adjuvant treatment	No	1						1
	Yes	0.587		0.379	0.91	0.017		0.517	0.311		0.86	0.011

DM: Diabetes mellitus; HT: Hypertension; LCC: Left colon cancer; LVI: Lymphovascular invasion; pN: Pathological lymph node stage; PNI: Perineural invasion; pT: Pathological tumor stage; RCC: Right colon cancer.