Prognostic value of vascular endothelial growth factor receptor 1 and class III β-tubulin in survival for non-metastatic rectal cancer

Table 3 Cox regression analysis for overall survival

Variables	Univariate			Multivariate
	HR	95%CI	P	HR	95%CI	P
Gender
Female/male	1.018	0.519-1.997	0.958
Age
≤ 60/> 60	1.175	0.548-2.518	0.679
Pre-CEA
≤ 5/> 5	1.067	0.496-2.298	0.868
Pre-Hb
≤ 120/> 20	0.651	0.328-1.290	0.219
Distance to verge (cm)
≤ 5/> 5	1.265	0.642-2.491	0.497
T stage
T1 + T2/T3 + T4	4.221	1.011-17.632	0.048	4.05	0.968-116.93	0.055
Lymph node metastasis
Negative/positive	6.247	1.905-20.491	0.003	3.042	1.137-8.142	0.027
Tumor thrombus
Negative/positive	1.303	0.458-3.705	0.62
Tumor differentiation
Poorly/moderately-well	0.503	0.251-1.006	0.052	-	-	0.18
Chemotherapy
No/yes	1.407	0.430-4.605	0.572
TUBB3 expression
Low/high	2.407	1.188-4.877	0.015	-	-	0.1
VEGFR1 expression
Low/high	2.817	1.424-5.570	0.003	2.151	1.062-4.355	0.033

Pre-CEA: Preoperative carcino-embryonic antigen; Pre-Hb: Preoperative hemoglobin.