Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase II study

Table 5 Biological equivalent doses[44]

	Tumor control/acute normal tissue complication probability		Late normal tissue complication probability
	Bed (Gy) (α/β = 10 Gy)		Bed (Gy) (α/β = 3 Gy)
Regimen	No time correction	With time correction
25 Gy/5 fr/5 d (d = 5 Gy)	37.5	37.5	66.7
50 Gy/25 fr/33 d (d = 2 Gy)	60.0	44.4	83.4
42 Gy/28 fr/18 d (d = 1.5 Gy)	48.3	41.7	63.0

Equation 1: Linear quadratic based isoeffect, basic formula without time correction, BED = nd (1+d/α/β), where n = number of fractions, d = dose (Gy) per fraction, α/β = the LQ quotient, Equation 2: Time-corrected LQ- formula, BED = nd (1+d/α/β)-γ/α (T- Tk), where γ/α = repair rate (set to 0.6 Gy/d), T = overall treatment time and Tk = proliferation delay (set to 7 d, or maximally T).