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©The Author(s) 2018.
World J Gastrointest Oncol. Jan 15, 2018; 10(1): 15-22
Published online Jan 15, 2018. doi: 10.4251/wjgo.v10.i1.15
Published online Jan 15, 2018. doi: 10.4251/wjgo.v10.i1.15
Publications | Number of cases | Sensitivity | Specificity | Algorithm | Assay used | Ref. |
Tóth et al (2012) | 184 (92 CRC, 92 no evidence of disease) | 95.6% | 84.8% | 1/3 | Epi proColon 2.0 | [27] |
(95%CI: 89.2%-98.8%) | (95%CI: 75.8%-91.4%) | |||||
79.3% | 98.9% | 2/3 | ||||
(95%CI: 69.6%-87.1%) | (95%CI: 94.1%-100%) | |||||
Church et al (2014) | 1516 (53 CRC, 1457 without CRC) | 48.2% | 91.5% | 1/3 | Epi proColon 1.0 | [31] |
(95%CI: 32.%-63.6%) | (95%CI: 89.7%-93.1%) | |||||
Potter et al (2014) | 1544 (44 CRC, 1500 non-CRC) | 68.0% | 80.0% | - | Epi proColon 1.0 | [34] |
(95%CI: 53%-80%) | (95%CI: 78%-82%) | |||||
Su et al (2014) | 234 (172 CRC, 62 controls) | 88.4% | 93.5% | - | MSP-DHPLC | [28] |
Johnson et al (2014) | 301 (101 CRC, 200 non-CRC) | 73.3% | 81.5% | - | Epi proColon 1.0 | [32] |
(95%CI: 63.9%-80.9%) | (95%CI: 75.5%-86.3%) | |||||
Jin et al (2014) | 476 (135 CRC, 341 non-CRC) | 74.8% | 87.4% | 2/3 | Epi proColon 2.0 | [29] |
(95%CI: 67.0%-81.6%) | (95%CI: 83.5%-90.6%) | |||||
Ørntoft et al (2015) | 300 (150 CRC, 150 controls) | 73.0% | 82.0% | 1/3 | Epi proColon 1.0 | [33] |
(95%CI: 64%-80%) | (95%CI: 75%-88%) | |||||
Sharif et al (2016) | 90 (45 CRC, 45 controls) | 84.4% | 99.0% | - | MS-HRM assay | [52] |
Wu et al (2016) | 1031 (291 CRC, 740 non-CRC) | 73.0% | 97.5% | - | Epi proColon 2.0 | [30] |
76.6% | 95.9% | - | New SEPT9 assay | |||
(95%CI: 71.3%-81.4%) | ||||||
Nian et al (2016) | 25 studies, 9927 samples (2975 (CRC, 6952 non-CRC) | 71.0% | 92.0% | 2/3 | Epi proColon 2.0 | [35] |
(95%CI: 67%-75%) | (95%CI: 89%-94%) |
- Citation: Wang Y, Chen PM, Liu RB. Advance in plasma SEPT9 gene methylation assay for colorectal cancer early detection. World J Gastrointest Oncol 2018; 10(1): 15-22
- URL: https://www.wjgnet.com/1948-5204/full/v10/i1/15.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v10.i1.15