Russell body gastritis with Dutcher bodies evaluated using magnification endoscopy

Figure 2 Pathological features of the antral lesion. The biopsy specimen stained by hematoxylin and eosin shows chronic gastritis with crowded granulated cells (A, B). The histiocytoid cells have fine eosinophilic granules similar to those of eosinophils (C). Intranuclear cytoplasmic granules suggesting Dutcher bodies are observed (D). E-F: The ESD specimen stained by hematoxylin and eosin shows that the lesion (E, indicated by a dotted line) is edematous and demarcated and includes many granulated cells (F). G-J: Immunohistochemical (G-H) and in situ hybridization (I-J) findings with ESD specimens show that the granulated cells (arrowheads) are positive for CD79a (G), multiple myeloma oncogene 1 (H), and kappa (I) and negative for lambda (J), while plasma cells without cytoplasmic granules are polyphenotypic.