Endoscopy-guided ablation of pancreatic lesions: Technical possibilities and clinical outlook

Table 3 Characteristics and findings of studies of endoscopic ultrasound-guided alcohol ablation in pancreatic cystic lesions

Ref.	Year	No.	Ablative agent	Clinical diagnosis (%)	Size mm (range)	Septated cysts n (%)	Follow-up months (range)	Complications	Percentage of ablated cysts
Gan et al[5]	2005	25	Ethanol	MCN 56%, IPMN 12%, SCA 12%, PCs 4%, unknown 8%	19.4 mean (6-37)	7 (28)	6-12	0%	35%
Oh et al[72]	2008	14	Ethanol and paclitaxel	MCN 14%, SCA 2%, lymphangioma 21%, unknown 43%	25.5 median (17-52)	3 (21.4)	9 median (6-23)	AP (7%)	79%
Oh et al[73]	2009	10	Ethanol and paclitaxel	MCN 30%, SCA 40%, unknown 30%	29.5 median (20-68)	10 (100)	8.5 median (6-18)	AP (10%)	60%
DeWitt et al[75]	2009	42	Ethanol vs saline	MCN 40%, IPMN 40%, SCA 12%, PCs 7%	20.5 (10-40)	17 (40.5)	3-4 mo after 2nd lavage	AP (2.4%), intracystic bleeding (2.4%), abdominal pain (24%), major complications, (24%)	33% (ethanol) 0% (saline)
Oh et al[74]	2011	52	Ethanol and paclitaxel	MCN 17%, SCA 29% PCs 4%, unknown 50%	31.8 (17-68)	20 (38.5)	21.7 mean (2-44)	Fever (2%), AP (2%), abdominal pain (2%), splenic vein obliteration (2%)	62%
DiMaio et al[76]	2011	13	Ethanol	IPMN 100%	20.1 mean (13-27.2)	7 (54)	3-6 mo after 2nd lavage	Abdominal pain (15%)	38%
Park et al[77]	2016	91	Ethanol	Indeterminate	30 (20-50)	64 (70)	40 median (13-117)	Fever (9%), abdominal pain (20%) AP (3%)	45%
Moyer et al[78]	2016	10	Ethanol or saline plus paclitaxel and gemcitabine	MCN 70%, IPMN 30%, unknown 10%	30	Unilocular predominantly	12	AP (10 %)	75% (ethanol plus paclitaxel and gemcitabine) 67% (alcohol free harm)

MCN: Mucinous cystic neoplasm; IPMN: Intraductal papillary mucinous neoplasm; SCA: Serous cystadenoma; PC: Pseudocyst; AP: Acute pancreatitis.