Diagnostic and therapeutic biomarkers in pancreaticobiliary malignancy

doi:10.4253/wjge.v8.i3.128

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World Journal of Gastrointestinal Endoscopy

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World J Gastrointest Endosc. Feb 10, 2016; 8(3): 128-142
Published online Feb 10, 2016. doi: 10.4253/wjge.v8.i3.128

Table 3 Prognostic markers in pancreatic ductal adenocarcinoma and cholangiocarcinoma

	Marker	Country	Total patients,n	Marker positive PDAC	Type of dysregulation	Prognostic value, OS months	HR or P value for OS
Pancreatic cancer	SPARC	United States[81]	299	200	Up-regulated	+SPARC: 15 -SPARC: 30	1.89
		Germany[83]	58	58	Up-regulated	+SPARC: 7.6 -SPARC: 10.2	2.23
		Germany[84]	160	95	Up-regulated	+SPARC: 17.9 -SPARC: 30.2	P = 0.006
		Japan[85]	104	104	Up-regulated	Decreased survival	2.92
		Sweden[82]	88	68	Up-regulated	+SPARC: 11.5 -SPARC: 25.3	2.12
	Marker	Country	Total Patients, n	CCA patients, n	Type of dysregulation	Prognostic value	HR (95%CI) or P value for OS
CCA	¹miR-192[130]	Japan	83	51	Up-regulated	Increased LN mets; shorter survival	2.076 (1.004-4.291) P < 0.05 mets
	miR-675-5p[88]	China	72	63	Up-regulated	Shorter survival	2.562 (1.295-4.929)
	miR-652-3p, miR-338-3p[88]	China	72	63	Down-regulated	Increased survival	0.477 (0.247-0.922); 0.498 (0.257-0.966)
	miR-151-3p and miR-126[156]	United States	32	32	Up-regulated and down-regulated, respectively	Increased survival	0.201 (0.043-0.928)
	¹miR-21[46]	Thailand, China	41	32	Up-regulated	Increased LN mets; shorter survival	P < 0.05 OS P = 0.037 mets
	miR-214[157]	China	14	14	Down-regulated	Increased mets	P < 0.05 mets
	miR-373[90]	China	48	48	Down-regulated	Shorter survival	P < 0.05 OS
	Group 1: miR-21, miR-31, miR-223 Group 2: miR-122, miR-145, miR- 146a, miR-200c, miR-221, and miR-222[44]	Greece	179	21	Group 1: Up-regulated Group 2: Down-regulated	None	-
	CYFRA 21-1[18,30]	United Kingdom, Japan	195	137	Up-regulated	Shorter survival	P = 0.001[30] P < 0.01[18]
	EGFR[93,94]	Japan	373	338	Up-regulated	Shorter survival	5.655 (2.72–11.74)[93] 2.67 (1.52-4.69)[94]

¹Liver fluke-associated CCA. PDAC: Pancreatic ductal adenocarcinoma; CCA: Cholangiocarcinoma; mets: Metastases; OS: Overall survival; SPARC: Secreted protein acidic and rich in cysteine; CYFRA 21-1: Cytokeratin 19 fragment; EGFR: Epidermal growth factor receptor; LN: Lymph node.

Citation: Viterbo D, Gausman V, Gonda T. Diagnostic and therapeutic biomarkers in pancreaticobiliary malignancy. World J Gastrointest Endosc 2016; 8(3): 128-142
URL: https://www.wjgnet.com/1948-5190/full/v8/i3/128.htm
DOI: https://dx.doi.org/10.4253/wjge.v8.i3.128