Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy: Canadian tertiary center experience

Table 5 Multivariable prediction model for high Fentanyl and Midazolam doses

Pre-procedural variables	Measurement units	Odds ratio, 95%CI; P value
Age	10-yr	0.62, 0.52-0.73; P < 0.0001
Gender	Female vs male	2.31, 1.32-4.05; P = 0.01
Previous colonoscopy with high sedation	Yes vs no	1.98, 1.15-3.42; P = 0.02
Previous surgery	Yes vs no	1.33, 0.78-2.25; P = 0.25
Current use of opioids, benzodiazepines or antidepressants	Yes vs no	2.50, 1.47-4.27; P = 0.004
Indications (reference - screening)	Bleeding	1.90, 1.03-3.51; P = 0.04
	Abdominal pain	3.07, 1.29-7.31; P = 0.01
	Change in BM	1.45, 0.71-2.97; P = 0.30
	IBD	3.01, 1.43-6.35; P = 0.01

BM: Bowel movements; IBD: Inflammatory bowel disease.