Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy: Canadian tertiary center experience

Table 4 Multivariate regression analysis of both Fentanyl > 50 mcg and Midazolam > 3 mg

Variable for Fentanyl > 50 mcg and midazolam > 3 mg	Coefficient	P value	OR (95%CI)
Age	-0.04	< 0.0001	0.95 (0.94-0.95)
Indication for endoscopy (reference - screening)
Bleeding	-0.11	0.18	0.89 (0.76-1.05)
Abdominal pain	0.37	0.01	1.45 (1.08-1.96)
Change in BM	0.13	0.18	1.14 (0.93-1.40)
IBD	0.37	0.02	1.45 (1.04-2.032)
Intraprocedural characteristics
Difficult procedure	0.55	< 0.0001	1.73 (1.48-2.03)
Interventions	0.1	0.12	1.10 (0.97-1.25)
Past history
Abdominal surgery	0.30	< 0.0001	1.33 (1.17-1.52)
Colonoscopy	0.33	0.0001	1.39 (1.21-1.60)
Medication/substance use
Opioids	0.41	0.46	0.49 (0.07-3.36)
Benzodazepines	0.36	0.36	3.76 (0.21-64)
Antidepressants	0.22	0.6	0.48 (0.03-7.76)
Alcohol	0.23	0.02	1.26 (1.03-1.54)

BM: Bowel movements; IBD: Inflammatory bowel disease.