Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy: Canadian tertiary center experience

Table 3 Multivariate logistic regression analysis for midazolam dose > 3 mg

Variable for midazolam > 3 mg	Coefficient	P value	OR (95%CI )
Age	-0.05	0.0001	0.94 (0.939-0.95)
Female gender	-0.06	0.0004	0.78 (0.68-0.89)
Indication for endoscopy (reference - screening)
Bleeding	-0.41	0.0001	0.65 (0.56-0.77)
Abdominal pain	0.38	0.032	1.46 (1.03-2.08)
Change in BM	0.02	0.849	1.02 (0.82-1.25)
IBD	0.19	0.346	1.21 (0.81-1.80)
Intraprocedural characteristics
Difficult procedure	0.50	0.0001	1.64 (1.38-1.96)
Past history
Abdominal surgery	0.31	0.0001	1.37 (1.20-1.57)
Medication/substance use
Opioids	0.38	0.025	1.47 (1.04-2.07)
Antidepressants	0.33	0.018	1.39 (1.11-1.73)

IBD: Inflammatory bowel disease; BM: Bowel movements.