Identification of factors associated with sedation tolerance in 5000 patients undergoing outpatient colonoscopy: Canadian tertiary center experience

Table 2 Multivariate logistic regression analysis for Fentanyl dose > 50 mcg

Variable for fentanyl > 50 mcg	Coefficient	P value	OR (95%CI)
Age	-0.04	0.0001	0.957 (0.952-0.963)
Indication for endoscopy (reference - screening)
Bleeding	-0.04	0.62	0.96 (0.82-1.12)
Abdominal pain	0.29	0.06	1.34 (0.99-1.81)
Change in BM	0.07	0.44	1.08 (0.88-1.31)
IBD	0.46	0.009	1.59 (1.22-2.49)
Intraprocedural characteristics
Difficult procedure	0.45	0.0001	1.57 (1.34-1.81)
Intervention	0.15	0.013	1.17 (1.033-1.32)
Bad preparation	0.16	0.14	1.17 (0.94-1.45)
Past history
Abdominal surgery	0.33	0.0001	1.40 (1.23-1.59)
Colonoscopy	0.26	0.0002	1.30 (1.13-1.49)
Current medications/substance use
Opioids	0.34	0.028	1.40 (1.03-1.91)
Benzodiazepines	0.37	0.017	1.45 (1.06-1.98)
Antidepressants	0.26	0.009	1.30 (1.06-1.60)
Alcohol (any vs none)	0.23	0.022	1.26 (1.03-1.54)

IBD: Inflammatory bowel disease; BM: Bowel movements.