Outcomes of submucosal (T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection

Table 1 Characteristics of T1b esophageal adenocarcinoma by treatment modality following endoscopic mucosal resection

	Group A (n = 16)	Group B (n = 9)	Group C (n = 7)	Group D (n = 21)	Overall (n = 53)
Average age, yr	75 ± 78	70 ± 14	62 ± 5	72 ± 13	71 ± 12
Median follow-up after EMR, mo (range)	34 (12-102)	27 (12-56)	49 (13-103)	N/A	34 (12-103) (for groups A-C, n = 32)
EMR method, n (%)
Cap	6 (38)	0 (0)	2 (29)	4 (19)	12 (23)
Band	10 (62)	9 (100)	5 (71)	17 (81)	41 (77)
Pathology depth, n (%)
sm1	6 (38)	4 (44)	1 (14)	2 (10)	13 (25)
sm2/3	10 (62)	5 (56)	6 (86)	19 (90)	40 (75)
Tumor location, n (%)
Proximal two-thirds	2 (13)	1 (11)	1 (14)	5 (24)	9 (17)
Distal one-third	14 (88)	8 (89)	6 (86)	16 (76)	44 (83)
LPI, n (%)
Yes	1 (6)	1 (11)	0 (0)	3 (14)	5 (9)
No	15 (94)	8 (89)	7 (100)	18 (86)	48 (91)
Differentiation, n (%)
Well-moderate	14 (88)	6 (67)	7 (100)	15 (71)	42 (79)
Poor	2 (13)	3 (33)	0 (0)	6 (29)	11 (21)
EMR margins for cancer, n (%)
Deep -/lateral -	6 (38)	2 (22)	1 (14)	2 (10)	11 (21)
Deep -/lateral +	5 (31)	1 (11)	1 (14)	4 (19)	11 (21)
Deep +/lateral +	4 (25)	6 (66)	5 (71)	13 (62)	28 (53)
Deep +/lateral -	1 (6)	0 (0)	0 (0)	2 (10)	3 (6)
Recurrences, n (%)
Yes	6 (38)	1 (11)	2 (29)	N/A	9 (28)
No	10 (63)	8 (88)	5 (71)		23 (72)
Median time to recurrence (mo, range)	21 (6-73)	30 (30-30)	21 (7-35)		21 (6-73) (for groups A-C, n = 32)
Location of recurrence
Local	5	0	1	N/A	6
Metastatic	1	1	1		3

EMR: Endoscopic mucosal resection; LPI: Lymphatic/perineural invasion.