Clinical problems with antithrombotic therapy for endoscopic submucosal dissection for gastric neoplasms

Table 1 Multivariate analysis of risk factors for delayed bleeding: Antithrombotic therapy and patient and lesion characteristics

Ref.	No. of patients	Risk factor identified by multivariate analysis	OR (95%CI)	Risk factors identified by univariate analysis
Furuhata et al[36]	1781	HBT	10.04 (4.35-23.16)	HBT, multiple antithrombotic agents, tumor size greater than 20 mm, lower third location, UL+ tumors, operation time longer than 100 min, and cardiovascular disease
		Multiple antithrombotic agents	5.44 (2.00-14.79)
		Lower third location	2.17 (1.32-3.58)
		Operation time longer than 100 min	2.00 (1.25-3.20)
Matsumura et al[37]	413	CKD undergoing hemodialysis	33.86 (4.72-242.74)	HBT, tumor size over 40 mm, CKD undergoing hemodialysis
		HBT	5.77 (1.67-19.96)
		Lesion size greater than 40 mm	3.70 (1.09-12.52)

HBT: Heparin bridge therapy; CKD: Chronic kidney disease.