Evidence based review of the impact of image enhanced endoscopy in the diagnosis of gastric disorders

Table 1 Summary of studies using magnification with white light

Use in stomach	Type of evidence	Description	Remarks
Identification of normal gastric mucosa	Descriptive study[7]; Cross-sectional study with comparison to histology[8]	Normal corpus: Regular honeycomb pattern Normal antrum: Coil-shaped network with rare collecting venules	Different descriptive classifications have been used, but all emphasize on regular and uninterrupted mucosal and vascular patterns
Diagnosis of H. pylori gastritis	Six prospective studies with histology as the comparator[8-13]	High sensitivities and specificities for diagnosis of H. pylori	Multiple and varied pattern classifications with different endoscopes. Inherent subjectivity in classifications is an issue
Characterization of EGC	Six prospective studies with histology as the comparator[15-20]	Better results as compared to the traditional white light endoscopy	Multiple classifications bring inherent subjectivity; the most prevalent classification is the “VS” classification[17] which describes: Differentiated EGC: Irregular microvessels with a demarcation line Undifferentiated EGC: Absent demarcation line and absent sub-epithelial capillary networks

H. pylori: Helicobacter pylori; EGC: Early gastric cancer.